Macrophage Proliferation Is Regulated through CSF-1 Receptor Tyrosines 544, 559, and 807
نویسندگان
چکیده
منابع مشابه
CSF - 1 receptor - regulated macrophage proliferation 1 Macrophage Proliferation is Regulated Through CSF - 1 Receptor
Background: Activation loop Y807F or juxtamembrane domain Y559F mutations compromise CSF-1 receptor-mediated macrophage proliferation. Results: Tyr-559 suppresses constitutive proliferative activity of Tyr-807; ligand-induced Tyr559 phosphorylation relieves this inhibition and activates pathways. Conclusion: Tyr-807 drives proliferation. Tyr-559 confers ligand dependence. Significance: How indi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.355610